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National Institute of Health and Medical Research Inserm

France, Project Coordinator

The National Institute of Health and Medical Research (Inserm) is France’s leading public institution devoted to biomedical and health research.

Inserm plays a crucial role in advancing scientific knowledge and fostering healthcare innovation in France. Four research teams from Inserm are participating in the project.

Inserm A: Institute of Neurosciences of Montpellier (Basic Research)

The Institute of Neurosciences of Montpellier (INM) is a joint research unit supported by Inserm and the University of Montpellier, and the lead organisation for the ExpoSignalz project. INM is dedicated to research on the development and pathophysiology of the central and peripheral nervous systems, including sensory organs, as well as related diseases of genetic or environmental origin.

Dr Véronique Perrier

ExpoSignalz coordinator and Research Director at the National Centre for Scientific Research (CNRS)

Dr Véronique Perrier

ExpoSignalz coordinator and Research Director at the National Centre for Scientific Research (CNRS)

Véronique Perrier is the coordinator of ExpoSignalz and research lead for objective #3. She is a neurobiologist expert in the neuro-physiopathology of neurodegenerative diseases. After completing her PhD at the Pasteur Institute in Paris and a postdoctoral training on prion diseases at the UCSF, in the laboratory of Dr Stanley Prusiner (Nobel Prize of Medicine 1997), Dr. Perrier obtained a scientist position at the CNRS in Montpellier in 2000. Since 2015, her research has focused on the impact of environmental pollutants on neurodevelopment and neurodegenerative diseases. In 2021, she joined the Proteinopathies team at the Montpellier Institute of Neurosciences, where she led a group on “The role of environmental pollutants in neurodegenerative diseases”. She has received several awards for her research, Gene Therapy Prize from ThermoFisher in 2008, Chercheur d’Avenir Award in 2009 from Occitanie region, and the Drieu-Chollet Prize from the French National Academy of Medicine in 2020.

Dr Joan Torrent

Researcher

Dr Joan Torrent

Researcher

Joan is a leading researcher in the field of protein folding and amyloid formation. His work focuses on understanding how proteins misfold and aggregate, contributing to diseases such as Alzheimer’s. After completing his PhD at the University of Girona (Catalonia) in 2000, he carried out postdoctoral research in France on the mechanisms of amyloid formation.

In 2006, he launched his own research programme as a Senior Scientist at Inserm. He now leads a research group at the Institute for Neurosciences of Montpellier (INM), developing innovative approaches that combine protein biochemistry with advanced studies of amyloids, with the goal of improving diagnostics and unravelling the molecular mechanisms that drive amyloid polymorphism and toxicity.

Carole Crozet

Researcher

Carole Crozet

Researcher

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For almost 20 years, Carole has been working on pluripotent stem cells in the context of neurodegenerative diseases. She is now the head of the group “Stem cells and neurodegenerative diseases” at the Institute of Neurosciences of Montpellier. She has also previously been involved in several national and international projects.

Carole received two research prizes, and grants from the American CJD Foundation and was also the project manager of the Montpellier Center of Excellence in neurodegeneration (Montpellier-CoEN, AVIESAN Labelisation).

Cecile Monzo

Technician

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Inserm B: iBraiN Institute, Tours (Basic Research)

The Institute of Imaging, Brain and Neuropsychiatry (iBraiN) is a joint research unit supported by Inserm and the University of Tours, dedicated to advancing neuropsychiatric research. iBraiN integrates cellular, animal, and human studies to unravel the complex brain signatures of these disorders. By exploring brain network dysfunctions through a multidimensional and dynamic approach, it aims to develop personalised therapies.

Dr Julie Le Merrer

Director at the National Centre for Scientific Research (CNRS)

Dr Julie Le Merrer

Director at the National Centre for Scientific Research (CNRS)

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Julie is currently Research Director at CNRS and a neuroscientist specialising in behavioural psychopharmacology, reward processes, and social behaviour in mice. She holds a State Doctorate in Pharmaceutical Sciences (2000) and completed a PhD in Neurosciences and Pharmacology (1997–2002) at the University of Bordeaux, where she studied the role of mu opioid receptors in learning, anxiety, and motivation. Julie is leading research objective #4.

During her postdoctoral research at the University of Sussex, she explored the effects of alcohol withdrawal and cue conditioning. In 2006, she joined Brigitte Kieffer’s lab at IGBMC (Strasbourg), where she used knockout mice to investigate opioid receptor function, validated mu receptor-null mice as an autism model, and identified mGlu4 as a potential therapeutic target. Recruited by CNRS in 2014, she co-led a team with Jérôme Becker at PRC (the chemical risk prevention unit).

Since 2020, at iBrain, her research has focused on the neurobiology, environmental causes, and treatment of social deficits in neurodevelopmental disorders.

Inserm C: Institute of Neurosciences of Montpellier (Epidemiology)

The Institute for Neurosciences of Montpellier (INM) is a joint research unit affiliated with Inserm and the University of Montpellier. It is comprised of eight Inserm teams and a staff of 200 personnel working on sensory-motor deficits and neurodegeneration. INM aims to gather fundamental and translational research to study the development, synaptic plasticity and integration, and neurodegenerative processes leading to disorders of the central and sensory-motor systems.

Dr Marion Mortamais

Associate Professor, University of Montpellier

Dr Marion Mortamais

Associate Professor, University of Montpellier

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Marion is an Associate Professor at the University of Montpellier and is affiliated with the Institute for Neurosciences of Montpellier (Inserm U1298), within the NeuroPEPS team. She is an environmental epidemiologist whose research focuses on the impact of environmental exposures—particularly ambient air pollution—on human health, with a specific emphasis on brain ageing.

She has led or co-authored numerous peer-reviewed publications investigating the effects of ambient air pollution on cognitive decline and dementia in older adults, as well as on brain development in children.

Inserm D: CONSTANCES Cohort, Paris

CONSTANCES is France’s largest population-based cohort with 220,000 participants, officially recognised as a National Biology and Health Infrastructure by the French Ministry of Research, and aims, among other things, to provide a high-quality resource for researchers, both French and international, to explore a wide range of health-related questions. CONSTANCES is funded by the French government-supported programme “Investments for the Future” managed by the French National Research Agency, and it is supported by two other public agencies, the National Health Insurance Fund (CNAM) and the National Retirement Fund (CNAV).

Dr Emeline Lequy

Tenured Scientist, Inserm

Dr Emeline Lequy

Tenured Scientist, Inserm

Emeline works as a researcher at Inserm’s Population-Based Epidemiological Cohorts Unit and the Centre for Epidemiology and Population Health (CESP) in Paris. An engineer by training, and a PhD in agronomy completed at INRAe, the French National Research Institute for Agriculture, Food and Environment, she acquired extensive experience in environmental research and environmental epidemiology, particularly in characterising various residential exposures in the general population.

She has developed innovative methods for estimating exposure, with strong expertise in geomatics, especially in the CONSTANCES cohorts, for which she leads environmental health research. She has been involved in a dozen funded projects (including by Horizon Europe), and coordinates projects on air quality and climate change.